Time-frequency distribution analysis of heart rate and blood velocity variabilities in stage 24/34 chick embryos

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Title: Time-frequency distribution analysis of heart rate and blood velocity variabilities in stage 24/34 chick embryos
Author: Bonacci, Andrew
Abstract: Time-frequency distribution (TFD) analysis is a relatively new process for decomposing a complex signal to understand its spectral content Traditional signal spectral analysis examines both temporal and spectral contents distinctly. This method of analysis is suitable for signals where the spectral content is stationary and time-invariant. However, many naturally occurring signals are not only multicomponent, but are also highly time-variable, such as speech, heart rate variability, and other biological signals. Typically, the Fourier transform exposes sinusoidal frequencies present in a signal. It cannot, however, tell when these frequencies existed temporally. This is where timefrequency analysis excels over traditional spectral processing techniques. Time-frequency analysis allows the spectral content of the signal to be determined as well as when these frequency components occurred. The process can be thought of as time dependent Fourier analysis. The following thesis explores the effectiveness of time-frequency analysis for examining heart rate and blood velocity variability of dorsal aortic blood flow in developing chick embryos. These hemodynamic data series are used to assess embryonic cardiovascular function.. It is hoped that this thesis aids in the creation of cluneal tools for the early identification of functional heart defects in a developing human fetus. These heart defects can lead to serious heart disease later in life. Clinical treatments of morphological and functional heart defects are possible if they can be identified during early embryo/fetal development The time-frequency analysis performed, utilized the binomial distribution with a Hanning window as the input parameters. Through the use of Discrete Time Frequency Laboratory (DTFL) software, TFD analysis appears to be an effective tool for functional assessment of cardiovascular health during development.
Record URI: http://hdl.handle.net/1850/12345
Date: 1996-11

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