Studies toward the total synthesis of eletefine

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Title: Studies toward the total synthesis of eletefine
Author: Ahmed, Ijaz
Abstract: A method towards the total synthesis of eletefine is described. Two related convergent syntheses are explained which divide the molecule into two fragments. Improvements towards the synthesis of a bis-functionalized isoquinoline fragment are explained. Expansion on the knowledge and understanding of the isoquinoline system is also described. The synthesis illustrated entails a bromination of a triflate functionalized isoquinoline system and a regio-selective Sonogashira reaction. Suggestions towards the completion of the total synthesis are prescribed.
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Date: 2010-07

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