Discovering inner ear and central auditory system cellular pathways that might contribute to age-related hearing loss

Show full item record

Title: Discovering inner ear and central auditory system cellular pathways that might contribute to age-related hearing loss
Author: Liu, Xiaoxi
Abstract: Age-related hearing loss (ARHL) is a prevalent communication problem among senior citizens. Previous work (Tadros et al., 2008) has revealed genes which change their expression significantly with aging and hearing loss. However, this study is limited as it mainly focuses on apoptosis-related genes. Genes that regulate biological pathways other than apoptosis might also contribute to the development of age-related hearing loss, as suggested by some studies (Tadros et al., 2007; Souza et al., 2008). In order to circumvent this limitation and to better understand the underlying mechanisms of this communication problem, a free computational tool called Gene Set Enrichment Analysis (GSEA) is used to analyze the microarray data of aging cochlea and brain. Results show that most of the pathways which are up-regulated with aging/hearing loss in cochlea play a role in apoptosis and/or inflammation, suggesting that these two processes might be crucial for the development of ARHL. In contrast to the results from the cochlea, results for the aging brain indicate that cell cycle arrest is involved in deficits in the central auditory system with age.
Record URI: http://hdl.handle.net/1850/13435
Date: 2011-01-07

Files in this item

Files Size Format View
XLiuThesis1-7-2011.pdf 727.3Kb PDF View/Open

The following license files are associated with this item:

This item appears in the following Collection(s)

Show full item record

Search RIT DML


Advanced Search

Browse