Microarray analysis of gene expression profiles of tetrahymena H2B ubiquitylation mutant strains

Show full item record

Title: Microarray analysis of gene expression profiles of tetrahymena H2B ubiquitylation mutant strains
Author: Wang, Zhe
Abstract: Microarray analyses were performed to compare the gene expression profiles of wild-type and mutant strains of Tetrahymena thermophila. These studies suggest that, in Tetrahymena, ubiquitylation of histone H2B is not required for H3K4 methylation. Even though the E2 ubiquitin-conjugating enzyme Ubc2 and the E3 ubiquitin ligase Bre1 are required for H2B ubiquitylation, these two enzymes affect the expression of a much broader spectrum of genes than H2B ubiquitylation, suggesting that Ubc2 and Bre1 are involved in pathways other than H2B ubiquitylation in Tetrahymena.
Record URI: http://hdl.handle.net/1850/13747
Date: 2010-08-24

Files in this item

Files Size Format View
ZWangThesis8-24-2010.pdf 4.987Mb PDF View/Open

The following license files are associated with this item:

This item appears in the following Collection(s)

Show full item record

Search RIT DML


Advanced Search

Browse