Adenosine dialdehyde analogs I: regioselective synthesis of adenosine monoaldehydes

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Title: Adenosine dialdehyde analogs I: regioselective synthesis of adenosine monoaldehydes
Author: Neenan, J.; Opitz, S.; Cooke, C.; Morrill, Terence; Eckel, L.; Ussery, M.
Abstract: Selective borohydride reduction of adenosine dialdehyde (1) gave the known adenosine 2'-monoaldehyde (2). Reaction of 1 with N,N'-diphenylethylenediamine, followed by reduction and deblocking gave adenosine 3'-monoaldehyde (5), a new compound. Unlike 2, compound 5 inhibited S-AdoHcy hydrolase and showed antiviral activity in vitro.
Record URI: http://hdl.handle.net/1850/2138
Publishers URL: http://dx.doi.org/10.1016/0960-894X(96)00234-X
Date: 1996-06-18

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