Adenosine dialdehyde analogs I: regioselective synthesis of adenosine monoaldehydes

Show simple item record

dc.contributor.author Neenan, J. en_US
dc.contributor.author Opitz, S. en_US
dc.contributor.author Cooke, C. en_US
dc.contributor.author Morrill, Terence en_US
dc.contributor.author Eckel, L. en_US
dc.contributor.author Ussery, M. en_US
dc.date.accessioned 2006-07-19T18:38:40Z en_US
dc.date.available 2006-07-19T18:38:40Z en_US
dc.date.issued 1996-06-18 en_US
dc.identifier.citation Bioorganic and Medicinal Chemistry Letters 6N12 (1996) 1381-1386 en_US
dc.identifier.issn 0960-894X en_US
dc.identifier.uri http://hdl.handle.net/1850/2138 en_US
dc.description.abstract Selective borohydride reduction of adenosine dialdehyde (1) gave the known adenosine 2'-monoaldehyde (2). Reaction of 1 with N,N'-diphenylethylenediamine, followed by reduction and deblocking gave adenosine 3'-monoaldehyde (5), a new compound. Unlike 2, compound 5 inhibited S-AdoHcy hydrolase and showed antiviral activity in vitro. en_US
dc.format.extent 37365 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Elsevier: Bioorganic and Medicinal Chemistry Letters en_US
dc.subject Antiviral activity in vitro en_US
dc.title Adenosine dialdehyde analogs I: regioselective synthesis of adenosine monoaldehydes en_US
dc.type Abstract en_US
dc.identifier.url http://dx.doi.org/10.1016/0960-894X(96)00234-X

Files in this item

Files Size Format View

An open access version of this file is not available. Check "Publisher URL" field for access

This item appears in the following Collection(s)

Show simple item record

Search RIT DML


Advanced Search

Browse