A computational investigation of kinetoplastid trans-splicing

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Title: A computational investigation of kinetoplastid trans-splicing
Author: Gopal, Shuba; Awadalla, Saria; Gaasterland, Terry; Cross, George
Abstract: Trans-splicing is an unusual process in which two separate RNA strands are spliced together to yield a mature mRNA. We present a novel computational approach which has an overall accuracy of 82% and can predict 92% of known trans-splicing sites. We have applied our method to chromosomes 1 and 3 of Leishmania major, with high-confidence predictions for 85% and 88% of annotated genes respectively. We suggest some extensions of our method to other systems.
Record URI: http://hdl.handle.net/1850/2367
Publishers URL: http://dx.doi.org/10.1186/gb-2005-6-11-r95
Date: 2005-10-17

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