Possible epistatic role of ADH7 in the protection against alcoholism

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dc.contributor.author Osier, Michael en_US
dc.contributor.author Lu, Ru-Band en_US
dc.contributor.author Pakstis, Andrew en_US
dc.contributor.author Kidd, J. en_US
dc.contributor.author Huang, S. en_US
dc.contributor.author Kidd, K. en_US
dc.date.accessioned 2006-08-21T19:46:26Z en_US
dc.date.available 2006-08-21T19:46:26Z en_US
dc.date.issued 2004-04-01 en_US
dc.identifier.citation American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 126BN1 (2004) 19-22 en_US
dc.identifier.issn 1552-485X en_US
dc.identifier.uri http://hdl.handle.net/1850/2373 en_US
dc.description.abstract In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence for an additional effect from outside the Class I ADH genes, presumably from functional variation at the ADH7 gene. The protective effect is restricted to one of two haplotypes identical at ADH1B but differing at an intronic SNP at ADH7 suggesting epistasis or strong linkage disequilibrium (LD). en_US
dc.description.sponsorship United States National Institute of Alcohol Abuse and Alcoholism (to K.K.K.); Grant Number: AA09379, National Health Research Institute (to R.B.L.); Grant Number: Taiwan, ROC; NHRI-EX91-8939SP, National Science Council (to R.B.L.); Grant Number: Taiwan, ROC; NSC 90-2314-B-016-081 en_US
dc.format.extent 26196 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Wiley: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics en_US
dc.subject ADH7 en_US
dc.subject Alcoholism en_US
dc.subject Polymorphism en_US
dc.title Possible epistatic role of ADH7 in the protection against alcoholism en_US
dc.type Article en_US
dc.identifier.url http://dx.doi.org/10.1002/ajmg.b.20136

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