Considerable haplotype diversity within the 23kb encompassing the ADH7 gene.

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dc.contributor.author Han, Yi en_US
dc.contributor.author Oota, Hiroki en_US
dc.contributor.author Osier, Michael en_US
dc.contributor.author Pakstis, Andrew en_US
dc.contributor.author Speed, William en_US
dc.contributor.author Odunsi, Adekunle en_US
dc.contributor.author Okonofua, Friday en_US
dc.contributor.author Kajuna, Sylvester en_US
dc.contributor.author Karoma, Nganyirwa en_US
dc.contributor.author Kungulilo, Selemani en_US
dc.contributor.author Grigorenko, Elena en_US
dc.contributor.author Zhukova, Olga en_US
dc.contributor.author Bonne-Tamir, Batsheva en_US
dc.contributor.author Lu, Ru-Band en_US
dc.contributor.author Parnas, Joseph en_US
dc.contributor.author Schulz, Leslie en_US
dc.contributor.author Kidd, Judith en_US
dc.contributor.author Kidd, Kenneth en_US
dc.date.accessioned 2006-08-21T19:47:08Z en_US
dc.date.available 2006-08-21T19:47:08Z en_US
dc.date.issued 2005-12 en_US
dc.identifier.citation Alcoholism: Clinical & Experimental Research 29N12 (2005) 2091-2100 en_US
dc.identifier.issn 1530-0277 en_US
dc.identifier.uri http://hdl.handle.net/1850/2375 en_US
dc.description Article may be found at: http://www.alcoholism-cer.com/pt/re/alcoholism/abstract.00000374-200512000-00002.htm;jsessionid=GShXSQwCTTc7S540gNfgP4fhJ9nY6LYXvQn3MGGQhq8TFVJ2LLgr!-1082563917!-949856145!8091!-1 en_US
dc.description.abstract Background: Of the seven known human alcohol dehydrogenase (ADH) genes, the nonliver expressed ADH7 gene codes for the enzyme with the highest maximal activity for ethanol. Previous study from our laboratory has suggested that ADH7 has an epistatic role for protection against alcoholism based on a single ADH7 SNP. Methods: We have now studied seven SNPs, additional populations for the SNP previously examined, and six more new SNPs, across 23 kb of ADH7 in 38 population samples originating from different geographical regions of the world. Results: The overall linkage disequilibrium is moderate to strong across this region even though considerable 7-SNP haplotype diversity is observed. This uncommonly high haplotype diversity is explained by high LD within each "half," the three upstream SNPs and the four downstream SNPs, but near randomization between the "halves." This division significantly simplified the haplotype pattern: only four major haplotypes account for almost all chromosomes in all populations in each "half." Conclusions: The low linkage disequilibrium between these two "halves" suggests multiple recombination(s) have occurred in this region, specifically, within intron 7. The absence of strong LD between the functional variation in ADH1B that is strongly associated with alcoholism and any of the variation in ADH7 supports the genetic independence of ADH7 in association studies. Thus, the previously observed epistatic effect of ADH7 cannot be explained by its linkage disequilibrium with a causative factor in ADH1B. en_US
dc.format.extent 29143 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Blackwell: Alcoholism: Clinical & Experimental Research en_US
dc.subject ADH7 en_US
dc.subject Alcohol dehydrogenase en_US
dc.subject Haplotypes en_US
dc.title Considerable haplotype diversity within the 23kb encompassing the ADH7 gene. en_US
dc.type Article en_US

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