Variation in the interleukin 4 receptor alphagene confers susceptibility to asthma and atopy in ethnically diverse populations

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dc.contributor.author Ober, Carole en_US
dc.contributor.author Leavitt, Stephanie en_US
dc.contributor.author Tsalenko, Anya en_US
dc.contributor.author Howard, Timothy en_US
dc.contributor.author Hoki, Danessa en_US
dc.contributor.author Daniel, Rajeev en_US
dc.contributor.author Newman, Dina en_US
dc.contributor.author Wi, Xiaodong en_US
dc.contributor.author Parry, Rodney en_US
dc.contributor.author Lester, Lucille en_US
dc.contributor.author Solway, Julian en_US
dc.contributor.author Blumenthal, Malcolm en_US
dc.contributor.author King, Richard en_US
dc.contributor.author Xu, Jianfeng en_US
dc.contributor.author Meyers, Deborah en_US
dc.contributor.author Bleecker, Eugene en_US
dc.contributor.author Cox, Nancy en_US
dc.date.accessioned 2006-08-21T19:48:15Z en_US
dc.date.available 2006-08-21T19:48:15Z en_US
dc.date.issued 2000-02 en_US
dc.identifier.citation American Journal of Human Genetics 66N2 (2000) 517-526 en_US
dc.identifier.issn 0002-9297 en_US
dc.identifier.uri http://hdl.handle.net/1850/2379 en_US
dc.description Article may be found at: http://www.journals.uchicago.edu/AJHG/journal/issues/v66n2/991269/991269.html en_US
dc.description.abstract After a genomewide screen in the Hutterites was completed, the IL4RA gene was examined as the 16p-linked susceptibility locus for asthma and atopy. Seven known variants and one novel variant, representing all nonsynonymous substitutions in the mature protein, were examined in the Hutterites; on the basis of studies in the Hutterites, outbred white, black, and Hispanic families were genotyped for selected markers. All population samples showed evidence of association to atopy or to asthma (P values .039 .0044 for atopy and .029 .0000061 for asthma), but the alleles or haplotypes showing the strongest evidence differed between the groups. Overall, these data suggest that the IL4RA gene is an atopy- and asthma-susceptibility locus but that variation outside the coding region of the gene influences susceptibility. en_US
dc.description.sponsorship work was supported by NIH grants HL49596, HL56399, and HL49602. en_US
dc.format.extent 40288 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher University of Chicago Press: American Journal of Human Genetics en_US
dc.subject Asthma en_US
dc.subject Atopy en_US
dc.subject Polymorphism en_US
dc.title Variation in the interleukin 4 receptor alphagene confers susceptibility to asthma and atopy in ethnically diverse populations en_US
dc.type Article en_US

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