Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin

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Title: Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin
Author: Weiss, Lauren; Veenstra-VanderWeele, Jeremy; Newman, Dina; Kim, Soo-Jeong; Dytch, Harvey; McPeek, Mary; Cheng, Suzanne; Ober, Carole; Cook, Edwin Jr.; Abney, Mark
Abstract: Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) influencing whole blood serotonin in 567 members of a single large pedigree, using a novel association-based mapping approach. We identified an association between the beta 3 integrin (ITGB3) Leu33Pro polymorphism on 17q21 and whole blood serotonin levels (P-value=9.8 ´ 10-5). This variant explained the evidence for linkage in this region when included as a covariate in the linkage analysis (change in LOD from 1.87 to 0.16), indicating that ITGB3 may be an important serotonin QTL.
Record URI: http://hdl.handle.net/1850/2385
Publishers URL: http://dx.doi.org/10.1038/sj.ejhg.5201239
Date: 2004-11

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