Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree

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dc.contributor.author Newman, Dina en_US
dc.contributor.author Abney, Mark en_US
dc.contributor.author Dytch, Harvey en_US
dc.contributor.author Parry, Rodney en_US
dc.contributor.author McPeek, Mary en_US
dc.contributor.author Ober, Carole en_US
dc.date.accessioned 2006-08-21T19:50:26Z en_US
dc.date.available 2006-08-21T19:50:26Z en_US
dc.date.issued 2003-01-15 en_US
dc.identifier.citation Human Molecular Genetics 12N2 (2003) 137-144 en_US
dc.identifier.issn 1460-2083 en_US
dc.identifier.uri http://hdl.handle.net/1850/2387 en_US
dc.description.abstract Serum triglyceride (TG) level is a well-known risk factor for cardiovascular disease, a leading cause of morbidity and mortality in Western countries. Although genome-wide scans for TG have been conducted in several populations, few loci have shown strong evidence for linkage. The Hutterites are a founder population, which practices a communal lifestyle that includes a uniformly high-fat, high-cholesterol diet. We measured serum TG in 485 Hutterites 14 years old and performed a genome-wide scan to find genetic determinants of the observed variation in TG levels, using mapping methods that take advantage of the extensive inbreeding and linkage disequilibrium (LD) in this single, 1623-member pedigree. We report two highly significant associations with TG levels, alleles at D2S410 on 2q14 (locus P=5.8x10-6, genome-wide P=0.005) and at IFNA on chromosome 9p21 (locus P=4.3x10-5, genome-wide P=0.024). In each case, homozygosity at the locus is associated with low TG levels, suggesting that alleles at nearby loci may protect against high TG levels. en_US
dc.description.sponsorship This project was supported by NIH grants HL56399, HG01645 and DK55889, the NHLBI Mammalian Genotyping Service (Marshfield, WI, USA) and a grant from Hoffman-LaRoche Inc. en_US
dc.format.extent 28554 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press: Human Molecular Genetics en_US
dc.subject Homozygosity en_US
dc.subject Hutterites en_US
dc.subject Serum triglyceride en_US
dc.title Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree en_US
dc.type Article en_US
dc.identifier.url http://dx.doi.org/10.1093/hmg/ddg012

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