Clinical evaluation of two direct procedures for free thyroxin, and of free thyroxin index determined nonisotopically and by measuring thyroxin-binding globulin

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Title: Clinical evaluation of two direct procedures for free thyroxin, and of free thyroxin index determined nonisotopically and by measuring thyroxin-binding globulin
Author: Waud, John; Chan, Daniel; Drew, Helen; Oropeza, Manuel; Sucupira, Maria; Scheinin, Barbara; Garrison, Grace; Mayo, Marvin; Taylor, Eleanor; Stem, Juanita; Graham, David; Coyle, Joseph; Niebyl, Jennifer; Wagner, Henry Jr.
Abstract: We have investigated the clinical utility of two direct radioimmunoassays for free thyroxin, an enzyme-inhibition immunoassay, and a direct measurement of thyroxin-binding globulin (TBG) by radioassay. All assay methods correctly identified greater than or equal to 90% of euthyroid, hyperthyroid, and hypothyroid patients who had normal TBG concentrations. In patients with altered TBG concentrations, none of the assays correctly classified all categories of patients. However, the direct assays of free thyroxin concentrations were able to classify correctly more patients with altered TBG concentrations than did the free thyroxin index methods. The free thyroxin index methods evaluated may be acceptable for routine use, if the concentration of thyroxin and the measurement of TBG capacity are reported along with the index value. Patients with altered TBG concentrations included a group of euthyroid pregnant patients. Significant decreases in free thyroxin in the third trimester were detected by all the assays studied. For patients in the first and second trimester, the mean free thyroxin concentration measured varied with the assay method.
Description: Article may be found at: http://www.clinchem.org/cgi/reprint/29/11/1908
Record URI: http://hdl.handle.net/1850/2560
Date: 1983-11

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