Clinical evaluation of two direct procedures for free thyroxin, and of free thyroxin index determined nonisotopically and by measuring thyroxin-binding globulin

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dc.contributor.author Waud, John en_US
dc.contributor.author Chan, Daniel en_US
dc.contributor.author Drew, Helen en_US
dc.contributor.author Oropeza, Manuel en_US
dc.contributor.author Sucupira, Maria en_US
dc.contributor.author Scheinin, Barbara en_US
dc.contributor.author Garrison, Grace en_US
dc.contributor.author Mayo, Marvin en_US
dc.contributor.author Taylor, Eleanor en_US
dc.contributor.author Stem, Juanita en_US
dc.contributor.author Graham, David en_US
dc.contributor.author Coyle, Joseph en_US
dc.contributor.author Niebyl, Jennifer en_US
dc.contributor.author Wagner, Henry Jr. en_US
dc.date.accessioned 2006-08-29T18:33:29Z en_US
dc.date.available 2006-08-29T18:33:29Z en_US
dc.date.issued 1983-11 en_US
dc.identifier.citation Clinical Chemistry 29N11 (1983) 1908-1911 en_US
dc.identifier.issn 1530-8561 en_US
dc.identifier.uri http://hdl.handle.net/1850/2560 en_US
dc.description Article may be found at: http://www.clinchem.org/cgi/reprint/29/11/1908 en_US
dc.description.abstract We have investigated the clinical utility of two direct radioimmunoassays for free thyroxin, an enzyme-inhibition immunoassay, and a direct measurement of thyroxin-binding globulin (TBG) by radioassay. All assay methods correctly identified greater than or equal to 90% of euthyroid, hyperthyroid, and hypothyroid patients who had normal TBG concentrations. In patients with altered TBG concentrations, none of the assays correctly classified all categories of patients. However, the direct assays of free thyroxin concentrations were able to classify correctly more patients with altered TBG concentrations than did the free thyroxin index methods. The free thyroxin index methods evaluated may be acceptable for routine use, if the concentration of thyroxin and the measurement of TBG capacity are reported along with the index value. Patients with altered TBG concentrations included a group of euthyroid pregnant patients. Significant decreases in free thyroxin in the third trimester were detected by all the assays studied. For patients in the first and second trimester, the mean free thyroxin concentration measured varied with the assay method. en_US
dc.description.sponsorship We acknowledge the support, in the form of reagents supplied, of the following manufacturers: Clinical Assays, Amersham International, and Abbott Laboratories. en_US
dc.format.extent 35680 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher American Association for Clinical Chemistry: Clinical Chemistry en_US
dc.subject Enzyme immunoassay en_US
dc.subject Free thyroxin en_US
dc.subject Thyroid status en_US
dc.title Clinical evaluation of two direct procedures for free thyroxin, and of free thyroxin index determined nonisotopically and by measuring thyroxin-binding globulin en_US
dc.type Article en_US

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