A mathematical model of growth factor induced capillary growth in the retina

Show full item record

Redirect: RIT Scholars content from RIT Digital Media Library has moved from http://ritdml.rit.edu/handle/1850/5052 to RIT Scholar Works http://scholarworks.rit.edu/article/1107, please update your feeds & links!
Title: A mathematical model of growth factor induced capillary growth in the retina
Author: Maggelakis, Sophia; Savakis, Andreas
Abstract: Abnormal capillary growth in the retina has been recently associated with the presence of the Vascular Endothelial Growth Factor (VEGF). The production of VEGF is a result of oxygen starvation in the retina, which can take place as a consequence of inadequate capillary growth in premature babies or clogged capillaries in diabetics. When VEGF levels rise, they trigger abnormal blood vessel growth across the retina, and may cause damage, and sometimes permanent loss of vision. In this paper, a mathematical model that examines the effects of VEGF on the growth of retinal capillaries is presented. The model directly relates the production of VEGF to oxygen consumption. The diffusion equations for the concentrations of oxygen and VEGF are solved, and the capillary growth is determined as a function of the oxygen and VEGF concentrations.
Description: Only the article abstract is contained within the file associated with this article.
Record URI: http://hdl.handle.net/1850/5052
Date: 1996-10

Files in this item

Files Size Format View
MaggelakisAbstract10-1996.pdf 58.56Kb PDF View/Open

The following license files are associated with this item:

This item appears in the following Collection(s)

Show full item record

Search RIT DML

Advanced Search