Description and demonstration of a CMOS amplifier-based-system with measurement and stimulation capability for bioelectrical signal transduction

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dc.contributor.author Pancrazio, Joseph en_US
dc.contributor.author Bey, Paul Jr. en_US
dc.contributor.author Loloee, Arash en_US
dc.contributor.author Manne, SubbaRao en_US
dc.contributor.author Chao, Hui-Chuan en_US
dc.contributor.author Howard, Lorn en_US
dc.contributor.author Gosney, W. Milton en_US
dc.contributor.author Borkholder, David en_US
dc.contributor.author Kovacs, Gregory en_US
dc.contributor.author Manos, Patricia en_US
dc.contributor.author Cuttino, David en_US
dc.contributor.author Stenger, David en_US
dc.date.accessioned 2008-02-01T18:12:37Z en_US
dc.date.available 2008-02-01T18:12:37Z en_US
dc.date.issued 1998-10 en_US
dc.identifier.citation Biosensors & Bioelectronics 13 (1998) 971-979 en_US
dc.identifier.uri http://hdl.handle.net/1850/5555 en_US
dc.description RIT community members may access full-text via RIT Libraries licensed databases: http://library.rit.edu/databases/ en_US
dc.description.abstract An extracellular recording system incorporating an electrode array and an amplifier/stimulator CMOS chip is described and characterized. Important features of this custom VLSI chip include 16 instrumentation amplifiers with a gain of 50 and the incorporation of a cross-point array allowing designation of an extracellular microelectrode as either a stimulator or sensor. The planar array consisted of 32 microelectrodes, 14,um in diameter, and four larger reference electrodes. Microelectrodes, interconnecting traces, and bond pads were patterned with a 500-run layer of gold. The interconnecting traces were passivated with a I-,um thick layer of silicon nitride to provide chemical and electrical insulation and microelectrode impedance was lowered utilizing electrode position of platinum black. The amplifier exhibited a nearly flat frequency response with high pass and low pass corner frequencies of 0.7 Hz and 50 kHz, respectively. The input referred noise over the 50 kHz bandwidth was 12-16 ,uVRMS' well below the magnitude of previously reported extracellular potentials. Crosstalk between neighboring channels resulted in an output signal below the amplifier noise level, even for relatively large extracellular potentials. Using this system, extracellular recordings were demonstrated yielding typical peak-to-peak biopotentials of magnitude 0.9-2.1 mV and 100-400,uV for chick cardiac myocytes and rat spinal cord neurons, respectively. The key components of this extracellular recording system can be manufactured using industry standard thin film photolithographic techniques. © 1998 Elsevier Science S.A. All rights reserved. en_US
dc.description.sponsorship The work at Southern Methodist University was supported in part by the late W. W. Caruth through the Communities Foundation of Texas, the National Science Foundation under Grant Nos. D1R-9109777 and D1R9317891, the University of North Texas, and the Texas Advanced Technology Program under Grant No. 003613-016. EffOlts at the Naval Research Laboratory and Science Application International Corporation were supported by the OSD Counterproliferation Support Program through DARPA and the Naval Research Laboratory contract N000 14-95-C-2128. The opinions and assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the view of the Department of the Navy. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier www.elsevier.com/locate/bios en_US
dc.subject Amplifier en_US
dc.subject Cardiac myocytes en_US
dc.subject CMOS en_US
dc.subject Extracellular recording en_US
dc.subject Spinal cord neurons en_US
dc.title Description and demonstration of a CMOS amplifier-based-system with measurement and stimulation capability for bioelectrical signal transduction en_US
dc.type Article en_US
dc.identifier.url http://dx.doi.org/10.1016/S0956-5663(98)00006-2

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