An approach to the classification of unknown biological agents with cell based sensors

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Title: An approach to the classification of unknown biological agents with cell based sensors
Author: Borkholder, David; DeBusschere, B. Derek; Kovacs, Gregory
Abstract: The broad-spectrum sensitivity of cell based biosensors offers the capability for detecting previously unknown biological agents. One cellular parameter that is often measured is the action potential of electrically active cells. However, the complexity of this signal makes interpretation of the cellular response to a compound difficult to interpret. By analyzing shifts in the signal’s power spectrum, it may be possible to classify the ionic channels modulated by the agent. A system is described for the measurement of action potentials from cells cultured on a planar microelectrode array. Experimental results, simulations, and analyses are presented for three pharmaceuticals tested on chick myocardial cells. While the actual agents could readily be distinguished experimentally, the models used for simulation were a partial success, accurately predicting the response to one of the three agents tested.
Record URI: http://hdl.handle.net/1850/5767
Date: 1998-06-08

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