Impedance imaging for hybrid biosensor applications

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Title: Impedance imaging for hybrid biosensor applications
Author: Borkholder, David; Maluf, Nadim; Kovacs, Gregory
Abstract: The impedance characteristics of individual cell / electrode systems are used to monitor cellular viability, position, adhesion, and response to external stimuli in hybrid biosensor applications. A planar microelectrode array consisting of 36 platinized iridium electrodes (10 mm diameter) is used as a substrate for the culture of mammalian cells. Electrode impedance is monitored across the array as different environmental factors are changed. Maps of electrode impedance have been shown to correlate directly to cell positioning over an electrode and general cellular viability. Exposure to a well known voltage-gated Na+ channel blocker (tetrodotoxin) provided significant cellular response as compared to control electrodes without cells. The effective use of small electrodes (10 mm diameter) to study single cell / electrode interactions has been demonstrated.
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Date: 1996-06-03

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