Inter-modality non-rigid breast image registration using finite-element method

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dc.contributor.author Krol, Andrzej
dc.contributor.author Coman, Ioana
dc.contributor.author Mandel, James
dc.contributor.author Baum, Karl
dc.contributor.author Luo, min
dc.contributor.author Feiglin, David
dc.contributor.author Lipson, Edward
dc.contributor.author Beaumont, Jacques
dc.date.accessioned 2008-09-21T01:59:07Z
dc.date.available 2008-09-21T01:59:07Z
dc.date.issued 2003
dc.identifier.isbn 0-7803-8257-9
dc.identifier.issn 1082-3654
dc.identifier.uri http://hdl.handle.net/1850/7062
dc.description IEEE nuclear science symposium conference record. en_US
dc.description.abstract We have investigated a new approach for co-registration of functional PET images with anatomical MR images for breast-cancer detection. This registration is required for multimodality PET-MRI breast image fusion, an approach that could prove useful as an alternative to surgical breast biopsy, following equivocal or difficult-to-interpret mammograms. Our method uses fiducial skin markers placed on the breast that can be observed in PET and MRI. The intermodal geometrical displacements (i.e. differences between PET and MRI marker locations) are estimated from tomographic images. A finite-element-method (FEM) model of breast tissue, based upon an analogy between the orthogonal components of the displacement field and a steady-state heat transfer (SSHT) problem was implemented. This equivalence is valid in that the displacement distribution problem is analogous to the SSHT in solids. The material properties of the breast appear here as coefficients of "thermal conductivity." Our model considers the observed marker displacements as FEM "temperature loads" and distributes them linearly (stepwise) over the entire breast volume. To test the performance of our method, an elastic breast phantom with simulated internal "lesions" and external markers placed on four meridians was imaged with PET and MRI. We estimated fiducial-registration errors and target-registration errors in the PET-MRI co-registration. The effects of the number, location, and distribution of the markers on the accuracy of the procedure were also investigated. We have established that multimodality breast-image co-registration using our SSHT FEM approach with external fiducial markers is accurate to within /spl sim/5 mm. en_US
dc.language.iso en_US en_US
dc.publisher IEEE en_US
dc.relation.ispartofseries Vol. 3 en_US
dc.title Inter-modality non-rigid breast image registration using finite-element method en_US
dc.type Article en_US

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