The First total synthesis of the proposed structure of Montiporyne E

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Title: The First total synthesis of the proposed structure of Montiporyne E
Author: Collison, Christina; Chen, Jian; Walvoord, Ryan
Abstract: Montiporyne E, a novel diacetylenic lactam isolated from the stony coral Montipora sp., was shown to exhibit cytotoxicity against certain solid tumor cells. Construction of a suitably functionalized α,β-unsaturated lactam for palladium-catalyzed couplings was realized via a Beckmann rearrangement. Subsequent Sonagoshira coupling with a known alkyne chain efficiently afforded the alleged structure of the natural product.
Record URI: http://hdl.handle.net/1850/7658
Publishers URL: http://dx.doi.org/10.1055/s-2006-942441
Date: 2006

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