Carcinogen specific dosimetry model for passive smokers of various ages

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dc.contributor.author Robinson, Risa
dc.date.accessioned 2008-12-12T13:17:27Z
dc.date.available 2008-12-12T13:17:27Z
dc.date.issued 2005
dc.identifier.uri http://hdl.handle.net/1850/7763
dc.description.abstract Studies indicate that being exposed to second hand smoke increases the chance of developing lung cancer. Understanding the deposition of carcinogenic particles present in second hand smoke is necessary to understand the development of specific histologic type cancers. In this study, a deposition model is presented for subjects of various ages exposed to sidestream smoke. The model included particle dynamics of coagulation, hygroscopic growth, charge and cloud behavior. Concentrations were varied from the maximum measured indoor concentrations (106 particles/cm3) to what would be expected from wisps of smoke (108 particles/cm3). Model results agreed well with experimental data taken from human subject deposition measurements (four studies). The model results were used to determine the dose intensity (dose per unit airway surface area) of Benzo[a]pyrene (BaP) in the respiratory tract for subjects of various ages. Model predictions for BaP surface concentration on the airway walls paralleled incident rates of tumors by location in the upper tracheobronchial region. Mass deposition efficiency was found to be larger for younger subjects, consistent with diffusion being the predominant mechanism for this particle size range. However, the actual dose intensity of BaP was found to be smaller for children than adults. This occurred due to the predominant effect of the smaller initial inhaled mass for children resulting from smaller tidal volumes. The resulting model is a useful tool to predict carcinogen specific particle deposition. en_US
dc.language.iso en_US en_US
dc.publisher Science of the total environment en_US
dc.subject Carcinogen en_US
dc.subject Dosimetry en_US
dc.subject Passive smokers en_US
dc.title Carcinogen specific dosimetry model for passive smokers of various ages en_US
dc.type Article en_US

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