Effect of multivariate process instability on principle component analysis: A Case study

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Title: Effect of multivariate process instability on principle component analysis: A Case study
Author: Holmes, Donald; Mergen, A. Erhan
Abstract: With the rising use of principal component analysis/partial least squares (PCA/PLS) in the process analytical technology (PAT) initiative of the pharmaceutical industry, it seems appropriate to view that approach from a statistical process control (SPC) perspective. The purpose of this study was to demonstrate the effect of process instability (i.e. state of statistical out-of-control) on use of PCA/PLS. The demonstrated differences in results should encourage PCA/PLS users to incorporate SPC as an active part of their process analytical control (PAC) toolkit to check for stability prior to drawing conclusions based on PCA/PLS analysis.
Record URI: http://hdl.handle.net/1850/8026
Date: 2005

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